Related Experiment Video
Updated: Jul 24, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
[The ionic mechanism of hyperpolarization induced by glucocorticoid and its modulatory effects in mammalian neurons]
1Department of Physiology, Second Military Medical University, Shanghai.
Abstract:
This is the first report to investigate the rapid hyperpolarization by glucocorticoid in coeliac ganglion neurons of guinea pig in vitro. Hydrocortisone 21-hemisuccinate (F-suc) caused rapidly hyperpolarization in neurons; hyperpolarization persisted after the elimination of synaptic inputs and after suppression of protein synthesis with actinomycin D; F-suc also induced hyperpolarization when picrotoxin or Ca(2+)-free in perfusion solution; TEA and 4-AP can inhibit the hyperpolarization of F-suc. These results provided evidence that F-suc's hyperpolarization may be mediated by potassium channel in the membrane. Also F-suc suppressed the discharges of neurons; and modulated rapidly effects of neurons to excitatory or inhibitory amino acids (P < 0.05).
Related Concept Videos
Hypothalamic-Pituitary Axis
Excitatory and Inhibitory Effects of Neurotransmitters
GPCRs Regulate Adenylyl Cylase Activity
Two...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Cushing Syndrome II: Pathophysiology

