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Treatment of erectile dysfunction: what should we do next?
T Tsukamoto1, Y Sato, H Horita
1Department of Urology, Sapporo Medical University School of Medicine, Japan. tukamoto@sapmed.ac.jp
World Journal of Surgery
|November 9, 2000
Summary
Sildenafil (Viagra) will soon be available, impacting erectile dysfunction (ED) treatment. Further research into testosterone replacement therapy is recommended for ED management.
Area of Science:
- Urology
- Pharmacology
- Neuroscience
Background:
- Erectile dysfunction (ED) is a common condition affecting many men.
- The upcoming clinical availability of sildenafil (Viagra) necessitates a re-evaluation of current ED treatment protocols.
Purpose of the Study:
- To discuss the anticipated impact of sildenafil on the diagnosis and treatment of ED.
- To explore potential favorable and unfavorable effects of sildenafil.
- To propose future research directions, including the role of testosterone replacement therapy (TRT).
Main Methods:
- Literature review and discussion of sildenafil's clinical implications.
- Presentation of experimental results from TRT in aged rats.
- Speculation on the neurobiological mechanisms of TRT in the brain's sex center.
Main Results:
- Sildenafil is expected to significantly alter the clinical approach to ED.
- Experimental data on TRT in aged rats provides insights into potential therapeutic mechanisms.
Conclusions:
- Urologists need to prepare for the integration of sildenafil into ED treatment paradigms.
- Further investigation into TRT and its central mechanisms is warranted for comprehensive ED management.