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Palisaded angioleiomyoma.

W Baugh1, M M Quigley, T L Barrett

  • 1Department of Dermatology, Naval Medical Center San Diego, California 92134-5000, USA. wpbaugh@nmcsd.med.navy.mil

Journal of Cutaneous Pathology
|December 2, 2000
PubMed
Summary
This summary is machine-generated.

A rare palisaded angioleiomyoma, a variant of vascular leiomyoma, was identified. This tumor exhibited Verocay body formation, mimicking neurilemoma on initial frozen section analysis.

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Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Oncology

Background:

  • Angioleiomyomas are benign vascular tumors of smooth muscle origin.
  • A rare histopathologic variant, palisaded angioleiomyoma, is characterized by prominent Verocay body formation.
  • Verocay bodies are typically associated with neural tumors like neurilemoma.

Observation:

  • A case of a subcutaneous nodule on the scalp of a 31-year-old male is presented.
  • Initial frozen section diagnosis suggested neurilemoma due to striking Verocay-like body formation.
  • Subsequent hematoxylin and eosin staining revealed features of angioleiomyoma.

Findings:

  • Immunohistochemistry confirmed smooth muscle differentiation with positive staining for actin and desmin.
  • The tumor was negative for S-100, ruling out a neural origin.
  • The combination of angioleiomyoma features and Verocay body formation is a novel finding.

Implications:

  • Palisaded angioleiomyoma represents a diagnostic challenge, potentially mimicking neural tumors.
  • This case expands the differential diagnosis for tumors exhibiting nuclear palisades.
  • Recognition of this variant is crucial for accurate histopathologic diagnosis and appropriate patient management.