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The Mouse Genome Database (MGD): integration nexus for the laboratory mouse
J A Blake1, J T Eppig, J E Richardson
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA. jblake@informatics.jax.org
Nucleic Acids Research
|January 11, 2000
Summary
The Mouse Genome Database (MGD) is a vital resource for mouse genetics research, providing integrated data on genes, sequences, and phenotypes. It enhances understanding of genotype-phenotype relationships for human disease research.
Area of Science:
- Genomics
- Bioinformatics
- Mammalian Genetics
Background:
- The laboratory mouse is a key model organism for human genome interpretation and disease research.
- Access to standardized, integrated data is crucial for advancing biological and disease studies.
Purpose of the Study:
- To describe the Mouse Genome Database (MGD) as a central resource for mouse genetics.
- To highlight MGD's role in integrating diverse datasets for genotype-phenotype analysis.
Main Methods:
- Curating and standardizing mouse gene nomenclature, map positions, and homology records.
- Integrating experimental datasets, chromosomal maps, and gene-to-sequence information.
- Developing enhanced representations for alleles and phenotypes.
Main Results:
- MGD provides a comprehensive, curated resource for the research community.
- Data integration and standardization facilitate transitions between sequence, gene, and phenotype annotations.
- Focus on allele and phenotype data improves exploration of genotype-phenotype relationships.
Conclusions:
- MGD is essential for understanding mouse biology and its relevance to human health.
- The database supports research by linking genomic information with biological phenotypes.
- MGD is critical for interpreting large-scale sequencing and mutagenesis project data.