Related Experiment Videos
Cortical networks recruited for time perception: a monkey positron emission tomography (PET) study
1Department of Neuroscience, Osaka Bioscience Institute, Osaka, 565-0874, Japan. onoe@tmin.ac.jp
Neuroimage
|January 3, 2001
Summary
Researchers identified key brain regions involved in time perception. The dorsolateral prefrontal cortex (DLPFC) and inferior parietal cortex are crucial for the brain's internal clock and temporal monitoring.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
Background:
- The brain's
- internal clock
- is hypothesized to govern time processing.
- Time keeping and perception are vital for integrated brain functions.
Purpose of the Study:
- To pinpoint brain regions active during time keeping and perception.
- To investigate the neural basis of temporal monitoring.
Main Methods:
- Positron emission tomography (PET) scans in rhesus monkeys.
- Measurement of regional cerebral blood flow (rCBF) as a neural activity index.
- Time discrimination tasks with durations from 400 to 1500 ms.
- Local application of bicuculline to disrupt dorsolateral prefrontal cortex (DLPFC) function.
Main Results:
- Significant rCBF changes correlated with perceived time durations were observed in the dorsolateral prefrontal cortex (DLPFC), posterior inferior parietal cortex, basal ganglia, and posterior cingulate cortex.
- Disruption of DLPFC function selectively impaired performance on time discrimination tasks.
Conclusions:
- A neural network involving the posterior inferior parietal cortex and DLPFC is critical for temporal monitoring in time perception.
- The DLPFC plays a significant role in accurate time discrimination.