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Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives
B Modzelewska-Banachiewicz1, E Jagiełło-Wójtowicz, E Tokarzewska-Wielosz
1Department of Organic Chemistry, Faculty of Pharmacy, Medicine University, 6 Staszica Str., 20-081 Lublin, Poland.
Acta Poloniae Pharmaceutica
|January 6, 2001
Abstract:
Synthesis of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives via the condensation of N'-substituted amidrazones and p-phenylenediisothiocyanate (PPD) is presented. The reaction conditions are discussed. Results of a preliminary pharmacological screening are presented.