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Fibrinogen and detached retina with or without proliferation
I P Theoharis1, G Mangouritsas, E Feretis
1Vitreoretinal Unit, B'Eye Clinic, Hellenic Red Cross Hospital, Athens, Greece. eteodoc@pan.gr
Acta Ophthalmologica Scandinavica
|February 13, 2001
Summary
Elevated fibrinogen plasma levels are linked to rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR). Higher fibrinogen levels were observed in RRD patients compared to controls, and even higher in PVR patients.
Area of Science:
- Ophthalmology
- Hematology
Background:
- Fibrinogen is a key protein involved in wound healing, inflammation, and cell proliferation.
- Understanding fibrinogen's role in ocular conditions is crucial for developing targeted therapies.
Purpose of the Study:
- To compare plasma fibrinogen levels in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR) after RRD.
- To investigate the potential correlation between fibrinogen levels and the development of RRD and PVR.
Main Methods:
- Plasma fibrinogen levels were measured preoperatively in three groups: controls (n=22), RRD patients (n=28), and PVR patients (n=20).
- Age-matched participants were selected, and individuals with diabetes or cardiovascular disease were excluded.
- T-Student's test was used to compare mean plasma fibrinogen levels between groups.
Main Results:
- Patients with RRD showed a statistically significant elevation in plasma fibrinogen levels compared to the control group (p=0.013).
- Patients with PVR exhibited significantly higher plasma fibrinogen levels than those with RRD (p=0.03).
Conclusions:
- The study suggests a positive correlation between elevated plasma fibrinogen levels and the occurrence of RRD.
- Findings indicate that fibrinogen may play a role in the pathogenesis of PVR following RRD.