Systemic therapy of psoriasis using methotrexate

If methotrexate were introduced as a new drug today, it would be hailed as a major advance in the management of psoriasis, as well as for a number of other conditions. Because the patent on methotrexate expired decades ago, this medication has not recently received the attention it deserves. When patients are properly screened and educated about the correct use of methotrexate, and appropriately monitored during treatment, this drug is a safe, inexpensive, well-tolerated and effective medication for the control of psoriasis.