Related Experiment Video
Updated: Aug 14, 2026

A Convenient and General Expression Platform for the Production of Secreted Proteins from Human Cells
Published on: July 31, 2012
Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes
V K Khavinson1, V G Morozov, V V Malinin
1Institute of Biological Regulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg. vvm@medport.ru
Abstract:
Lys-Glu in vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. It can not be excluded that Lys-Glu is a structural component of trans-acting factor active centers, which are necessary for the activation of interleukin-2 gene transcription in lymphocytes.

