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Pathomorphological characteristics of experimental toxemia induced by thermostable Yersinia pseudotuberculosis toxin
L M Isachkova1, N F Timchenko, E P Nedashkovskaya
1Institute of Epidemiology and Microbiology, Siberian Division, Russian Academy of Medical Sciences, Vladivostok, Russia.
Bulletin of Experimental Biology and Medicine
|February 22, 2001
Abstract:
Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organs. The toxin is believed to be directly involved in the development of typical pathomorphological picture of pseudotuberculosis, which confirms its pathogenetic role.