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Urticating Hashimoto-Pritzker Langerhans cell histiocytosis
D F Butler1, B D Ranatunge, R P Rapini
1Department of Dermatology, Texas Tech University, Health Sciences Center, Lubbock, Texas 79430, USA.derdfb@ttuhsc.edu
Pediatric Dermatology
|February 24, 2001
Abstract:
Red-brown papules developing during the neonatal period may present a diagnostic dilemma. The Darier sign has been a reliable feature in the diagnosis of mastocytosis. However, the cutaneous infiltrate of Hashimoto-Pritzker Langerhans cell histiocytosis (LCH) may contain a large number of mast cells, leading to confusion both clinically and histologically. We report an infant who developed red-brown papules of Hashimoto-Pritzker LCH during the neonatal period and presented with a positive Darier sign and acute urticaria.