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Steroid-dependent anosmia.

M H Stevens1

  • 1University of Utah School of Medicine, Salt Lake City 84106, USA.

The Laryngoscope
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Oral steroids can restore the sense of smell in patients with persistent anosmia after nasal and sinus polyp surgery. This treatment offers hope for improving olfactory function when other methods fail.

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Area of Science:

  • Otolaryngology
  • Rhinology
  • Olfactory dysfunction

Background:

  • Nasal and sinus polyps often cause anosmia (loss of smell).
  • Endoscopic sinus surgery is a common treatment, but some patients remain anosmic post-operatively.
  • Associated conditions include asthma, allergic rhinitis, and aspirin sensitivity.

Purpose of the Study:

  • To evaluate the effectiveness of steroid treatment in patients with persistent anosmia after endoscopic nasal and sinus polypectomy.
  • To determine if oral or topical steroids are more beneficial for restoring smell.

Main Methods:

  • A prospective study involving 24 patients with anosmia pre-surgery.
  • Olfactory testing was performed before and after surgery.
  • Patients remaining anosmic post-surgery received topical nasal steroids, followed by oral steroids if unresponsive.

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Main Results:

  • Twelve patients remained anosmic after surgery and did not respond to nasal steroids.
  • Oral steroids successfully restored the sense of smell in most of these patients.
  • Fear of side effects limited long-term oral steroid use.

Conclusions:

  • Oral steroids are an effective treatment for improving sense of smell in patients with persistent anosmia post-polypectomy.
  • The mechanism behind the differential response to oral versus nasal steroids requires further investigation.
  • Future research should explore the molecular basis of steroid action on olfactory function.