Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rheological properties of contraceptive gels.

D H Owen1, J J Peters, D F Katz

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, USA. dhowen@acpub.duke.edu

Contraception
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dutch Workflow for Diagnosis and Treatment of Velopharyngeal Insufficiency in Patients with Cleft Palate-A Survey Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2025
Same author

Imaging the development of the human craniofacial arterial system - an experimental study.

Pediatric radiology·2024
Same author

Factors predictive of patient outcome following total wrist arthrodesis.

The bone & joint journal·2016
Same author

Vaginal deployment and tenofovir delivery by microbicide gels.

Drug delivery and translational research·2015
Same author

An estimation of the incidence of squeaking and revision surgery for squeaking in ceramic-on-ceramic total hip replacement: a meta-analysis and report from the Australian Orthopaedic Association National Joint Registry.

The bone & joint journal·2014
Same author

Pneumoperitoneum as an Aid in Diagnosis.

Journal of the National Medical Association·2010
Same journal

Previous caesarean section and major complications during surgical abortion: a national multicentre case-control study.

Contraception·2026
Same journal

Quantification of residual levonorgestrel following extended use of the levonorgestrel 52 mg intrauterine device beyond 8 years.

Contraception·2026
Same journal

Mifepristone Provision Following Policy Shifts in 2022 & 2023.

Contraception·2026
Same journal

Bleeding Experience with Medication Abortion Prior to Embryonic Cardiac Activity.

Contraception·2026
Same journal

Importance of abortion training to residency program applicants: A national survey of OBGYN residents.

Contraception·2026
Same journal

Racial and Demographic Trends in Abortion Method Selection in Minnesota Among in-State Patients at or under 11 Weeks Gestational Duration, 2021-2024.

Contraception·2026
See all related articles

This study measured the rheological properties of four contraceptive gels, finding they exhibit non-Newtonian behavior essential for vaginal drug delivery. Gel properties varied significantly, impacting their performance and response to dilution.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Vaginal drug delivery systems require specific rheological properties for effective spreading and retention.
  • Understanding gel behavior is crucial for optimizing contraceptive efficacy and user experience.

Purpose of the Study:

  • To characterize the rheological properties of four commercial contraceptive gels.
  • To evaluate how dilution with vaginal fluid simulant affects these properties.

Main Methods:

  • Rheological measurements including stress growth, stress relaxation, residual stress, and viscosity.
  • Testing of Conceptrol, KY Plus, Gynol II, and Advantage-S gels and their dilutions.

Main Results:

  • All tested gels displayed non-Newtonian behavior, characterized by shear thinning and viscoelasticity.

Related Experiment Videos

  • Conceptrol and Gynol II showed no residual stress, unlike KY Plus and Advantage-S.
  • Significant differences were observed in how gels responded to dilution with vaginal fluid simulant.

    • Conclusions:

    • The rheological profiles of contraceptive gels vary, influencing their functional performance in vivo.
    • Dilution effects are critical considerations for the stability and efficacy of vaginal drug delivery systems.