Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retrograde amnesia.

L R Squire1, R E Clark, B J Knowlton

  • 1Veterans Affairs Healthcare System, San Diego, California 92161, USA. lsquire@ucsd.edu

Hippocampus
|March 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implicit and explicit learning of Bayesian priors differently impacts bias during perceptual decision-making.

Scientific reports·2021
Same author

Intact priming for novel perceptual representations in amnesia.

Journal of cognitive neuroscience·2013
Same author

Declarative and nondeclarative memory: multiple brain systems supporting learning and memory.

Journal of cognitive neuroscience·2013
Same author

New semantic learning in patients with large medial temporal lobe lesions.

Hippocampus·2008
Same author

Yes/no recognition, forced-choice recognition, and the human hippocampus.

Journal of cognitive neuroscience·2007
Same author

On the contribution of perceptual fluency and priming to recognition memory.

Cognitive, affective & behavioral neuroscience·2005
Same journal

Opioid-Associated Hippocampal Injury: Past, Present, and Future Directions.

Hippocampus·2026
Same journal

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.

Hippocampus·2026
Same journal

Intrinsic Persistent Firing in CA1 Encodes Elapsed Time Across Behaviorally Relevant Scales.

Hippocampus·2026
Same journal

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Hippocampus·2026
Same journal

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Hippocampus·2026
Same journal

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Hippocampus·2026
See all related articles

Animal studies confirm temporally graded retrograde amnesia, where recent memories are more affected than older ones after brain injury. This suggests memory reorganization over time, though underlying mechanisms require further investigation.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Animal Behavior

Background:

  • Temporally graded retrograde amnesia is a well-documented phenomenon in humans.
  • Experimental animal studies investigating this amnesia began in the 1990s.

Purpose of the Study:

  • To review and analyze experimental animal studies on temporally graded retrograde amnesia.
  • To explore reasons for inconsistent findings in these studies.
  • To identify future research directions for understanding memory reorganization mechanisms.

Main Methods:

  • Systematic review of 13 published studies involving animal training at multiple time points before fornix or hippocampal formation damage.
  • Analysis of findings related to the extent and temporal grading of retrograde amnesia.

Related Experiment Videos

Main Results:

  • Eleven of the 13 studies reported evidence of temporally graded retrograde amnesia.
  • Observed amnesia durations ranged from days to a couple of months.
  • Potential explanations for studies not observing this effect were considered.

Conclusions:

  • Substantial evidence supports temporally graded retrograde amnesia in animals.
  • The findings imply memory reorganization over time, but mechanisms remain unclear.
  • Further research involving targeted manipulations is recommended to elucidate these mechanisms.