Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Spontaneous regression and leukoderma in malignant melanoma].

R Happle, I Schotola, E Macher

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |March 1, 1975
    PubMed
    Summary

    Partial spontaneous regression and leukoderma in superficial spreading melanoma suggest an immune response. These changes may indicate the host

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Retrograde dilatation via gastrostomy of a proximal esophagoileal anastomotic stricture in an infant with esophageal atresia.

    Endoscopy·2009
    Same author

    Changes in skin physiology during bath PUVA therapy.

    The British journal of dermatology·2002
    Same author

    HID and KID syndromes are associated with the same connexin 26 mutation.

    The British journal of dermatology·2002
    Same author

    Differences of skin irritation between Japanese and European women.

    The British journal of dermatology·2002
    Same author

    [Unilateral atrophoderma following Blaschko's lines: Blaschkolinear morphoea or Moulin's linear atrophoderma?].

    Annales de dermatologie et de venereologie·2002
    Same author

    What is the 'true' function of skin?

    Experimental dermatology·2002

    Area of Science:

    • Dermatology
    • Oncology
    • Immunology

    Context:

    • Superficial spreading melanoma is a common form of cutaneous melanoma.
    • Spontaneous regression and leukoderma are observed in some melanoma cases.
    • Understanding these phenomena is crucial for melanoma prognosis and treatment.

    Purpose:

    • To investigate the occurrence and characteristics of partial spontaneous regression and leukoderma in superficial spreading melanoma.
    • To explore the potential link between these cutaneous changes and host-melanoma immunological interactions.

    Summary:

    • Four patients with superficial spreading melanoma exhibited partial spontaneous regression and/or leukoderma.
    • Leukoderma presented centrally within the primary tumor in two patients, with one also developing vitiligo.
    • Another case showed a depigmented halo around the melanoma, similar to Sutton's nevus.
    • These leukodermic changes are hypothesized to be epiphenomena of the host's specific immune response to melanoma.

    Impact:

    • Highlights the potential role of host immunity in melanoma regression and associated skin changes.
    • Suggests that leukoderma in melanoma patients may serve as a clinical indicator of an active immune response.
    • Informs further research into immunomodulatory therapies for melanoma.

    Related Experiment Videos