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Fusarium infection after solid-organ transplantation
1Division of Infectious Disease, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Summary
Fusarium infection in solid-organ transplant (SOT) recipients typically presents as localized disease with better outcomes compared to other transplant types. Effective treatment involves surgical removal and prolonged amphotericin therapy.
Area of Science:
- Mycology
- Transplant Infectious Diseases
- Immunocompromised Hosts
Background:
- Solid-organ transplant (SOT) recipients are at risk for opportunistic infections.
- Fusarium species are ubiquitous fungi that can cause invasive infections.
- Understanding infection patterns in SOT recipients is crucial for timely diagnosis and management.
Observation:
- A case of soft tissue infection caused by Fusarium species in a heart-liver transplant recipient is presented.
- A review of reported fusarial infections in SOT recipients was conducted.
- Fusarial infections in SOT recipients were compared to those in hematologic malignancy and bone marrow transplant patients.
Findings:
- Fusarial infections in SOT recipients are generally localized.
- These infections tend to occur later in the post-transplantation period.
- Outcomes for fusarial infections in SOT recipients are more favorable than in other transplant populations.
Implications:
- Early recognition and intervention are key for managing Fusarium infections in SOT recipients.
- Surgical resection, when feasible, is an important therapeutic component.
- Prolonged treatment with amphotericin demonstrates efficacy in treating these infections.