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Osteopenia in Puerto Ricans with Crohn's disease.

B Chinea1, A Rosa, J J Oharriz

  • 1Gastroenterology Research Unit, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, Puerto Rico, 00936-5067.

Puerto Rico Health Sciences Journal
|April 11, 2001
PubMed
Summary
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Osteopenia is common in Crohn's disease patients, affecting bone density in the hip and spine. No specific risk factors were identified, highlighting the need for regular bone density screening in these individuals.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Rheumatology

Background:

  • Osteopenia is a known complication of Inflammatory Bowel Disease (IBD), particularly Crohn's disease.
  • Factors like corticosteroid use, ileal resection, malabsorption, and inflammation contribute to bone density loss.
  • The prevalence in young adults, during peak bone mass acquisition, makes osteopenia in Crohn's disease particularly significant.

Purpose of the Study:

  • To assess bone density in patients with Crohn's disease at the University of Puerto Rico IBD Clinic.
  • To determine the prevalence of osteopenia in this patient cohort.
  • To identify potential correlations between bone mineral density and known risk factors for osteopenia.

Main Methods:

  • Sixty-six Crohn's disease patients (30 males, 36 females) provided informed consent.

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  • Demographic, clinical, and metabolic data were collected, including serum albumin, calcium, phosphorus, and alkaline phosphatase.
  • Bone mineral density was measured using DEXA scans of the lumbar spine and femur, with Z-scores used to define osteopenia.

    • Main Results:

    • A high prevalence of osteopenia was observed: 69% in the hip and 68% in the lumbar spine.
    • Steroid use was common, but no significant difference in osteopenia was found between treated and untreated patients.
    • Osteopenia did not correlate with ileal resection, gender, BMI, disease characteristics, or biochemical markers.

    Conclusions:

    • Low bone density is frequent in Crohn's disease patients.
    • No specific risk factors for osteopenia were identified in this study.
    • Routine bone density assessment is recommended for Crohn's disease patients to guide therapeutic interventions.