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Epinephrine causes a reduction in lymph node cell output in sheep.

T J Seabrook¹, B Ristevski, S G Rhind

¹Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. jack.hay@utoronto.ca

Canadian Journal of Physiology and Pharmacology

|April 11, 2001

Summary

Epinephrine (Epi) injection did not alter lymphocyte subsets or pools. Post-injection, lymph flow and cellularity decreased, suggesting lymph nodes may cause post-injection lymphopenia.

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Area of Science:

Physiology
Immunology
Lymphatic System Research

Background:

The lymphatic system is crucial for fluid, protein, and cell return to circulation.
The impact of physiological stress, like exercise, on the lymphatic system requires further investigation.

Purpose of the Study:

To investigate the effects of epinephrine on lymph flow, cell concentration, and lymphocyte subsets.
To understand the lymphatic system's response to physiological stress.

Main Methods:

Administered a physiological dose of epinephrine (1 mg) to sheep.
Monitored efferent subcutaneous lymph flow, cell concentration, and lymphocyte subsets.
Simultaneously analyzed blood leukocyte counts, differentials, and lymphocyte pools.

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Main Results:

Epinephrine injection caused an acute increase in lymph flow, followed by a decrease.
No significant changes were observed in lymphocyte subsets or total lymphocyte pools in blood or lymph.
Elevated plasma and lymph epinephrine and norepinephrine concentrations correlated with increased lymph flow.

Conclusions:

Epinephrine injection does not alter lymphocyte subset distribution or leukocyte concentration.
The lymphatic system does not play a role in epinephrine-induced leukocytosis.
Lymphocyte retention within lymph nodes may contribute to post-injection lymphopenia.