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Histone deacetylase complexes: functional entities or molecular reservoirs
1Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Equipe chromatine et expression des gènes, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, 38706 La Tronche Cedex, France. khochbin@ujf-grenoble.fr
FEBS Letters
|April 20, 2001
Summary
Nuclear complexes with histone deacetylases may act as dynamic molecular reservoirs. These abundant complexes likely exchange factors with smaller, functional complexes for specific cellular activities.
Area of Science:
- Molecular biology
- Biochemistry
- Epigenetics
Background:
- Increasing identification of nuclear multi-component complexes with enzymatic activities.
- Complexes containing histone deacetylases are implicated in transcription and chromatin remodeling.
Purpose of the Study:
- To propose a novel function for abundant nuclear complexes.
- To suggest these complexes act as "molecular reservoirs".
Main Methods:
- The study is based on recent investigations and theoretical suggestions.
- Analysis of existing data on nuclear complexes and histone deacetylases.
Main Results:
- Identification of numerous distinct nuclear multi-component complexes.
- Hypothesis that abundant complexes serve as dynamic reservoirs.
- These reservoirs exchange factors with less abundant, functional complexes.
Conclusions:
- Abundant nuclear complexes, particularly those with histone deacetylases, may function as "molecular reservoirs".
- These reservoirs facilitate dynamic exchange of factors to meet specific cellular demands.
- This dynamic model offers new insights into transcriptional regulation and chromatin remodeling.