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Brain and spinal cord atrophy in multiple sclerosis.

J H Simon1

  • 1Sections of Neuroradiology and MRI, Department of Radiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA. jack.simon@uchsc.edu

Neuroimaging Clinics of North America
|May 22, 2001
PubMed
Summary

Brain and spinal cord atrophy in multiple sclerosis (MS) occurs early and indicates irreversible damage. This early atrophy can now be accurately measured and may serve as a key prognostic indicator for MS progression.

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Area of Science:

  • Neuroscience
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) was previously thought to cause brain and spinal cord atrophy late in the disease course.
  • Atrophy was also considered a characteristic of rare, severe forms of MS.

Purpose of the Study:

  • To highlight the significance of early central nervous system (CNS) atrophy in multiple sclerosis (MS).
  • To discuss the potential of atrophy as a prognostic indicator and outcome measure in MS research and treatment.

Main Methods:

  • Accurate measurement of CNS atrophy over short intervals in MS patients.
  • Evaluation of atrophy as a potential biomarker for disease progression and treatment efficacy.

Main Results:

  • Central nervous system atrophy in MS is now understood to occur early in the disease process.

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  • This early atrophy is indicative of destructive and irreversible pathological changes, which may be subclinical.

    • Conclusions:

    • Early detection and measurement of CNS atrophy are crucial in managing multiple sclerosis.
    • Atrophy measurement shows promise as a future prognostic tool and treatment outcome measure for individuals with MS.