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Published on: June 13, 2017
[The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs]
1Department of Physiology and Biophysics, Li Ren Laboratory, Fudan University, Shanghai 200433.
Abstract:
It has been previously shown that the activation of A1 adenosine receptors in frog melanotroph induced a hyperpolarization accompanied by blockage of spontaneous action potentials. In the present report, we explored mechanisms underlying the above phenomenon using the patch-clamp technique in whole-cell and cell-attached configuration. The result showed that adenosine could increase the opening of non-voltage-activated potassium channels leading to hyperpolarization, but an inward cation current activated by hyperpolarizing pulse was not involved.
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