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In vitro effects of photodynamic therapy on Aspergillus fumigatus
J S Friedberg1, C Skema, E D Baum
1Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. joseph.friedberg@mail.TJU.edu
The Journal of Antimicrobial Chemotherapy
|June 22, 2001
Abstract:
Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 x 10(1) cfu/mL with a light dose of 110 J/cm(2) and up to 2.7 x 10(6) cfu/mL with a light dose of 385 J/cm(2).