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Effect of ACTH on pain sensitivity in rats
1Department of Physiology of Endocrine System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Bulletin of Experimental Biology and Medicine
|June 28, 2001
Abstract:
Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on pain sensitivity is probably mediated by short-term glucocorticoid-independent and long-term glucocorticoid-dependent mechanisms.