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Retinal nerve fiber layer and physiological central corneal thickness
Journal of Glaucoma
|July 10, 2001
Summary
Central corneal thickness does not significantly correlate with peripapillary retinal nerve fiber layer thickness measurements. However, corneal thickness showed a significant correlation with other standard Nerve Fiber Analyzer (GDx) parameters.
Area of Science:
- Ophthalmology
- Optometry
- Biomedical Optics
Background:
- Accurate measurement of retinal nerve fiber layer (RNFL) thickness is crucial for diagnosing and monitoring glaucoma.
- Central corneal thickness (CCT) can influence intraocular pressure (IOP) measurements, potentially affecting glaucoma diagnosis.
- The relationship between CCT and RNFL thickness, particularly when measured by specific devices, requires clarification.
Purpose of the Study:
- To investigate the correlation between central corneal thickness (CCT) and peripapillary retinal nerve fiber layer (RNFL) thickness.
- To assess the relationship between CCT and various parameters obtained from the Nerve Fiber Analyzer (GDx).
Main Methods:
- A study involving 44 eyes with normal visual fields and healthy optic nerve heads.
- RNFL thickness and GDx parameters were measured using a confocal scanning laser polarimeter (GDx).
- Corneal thickness was measured using an ultrasonic pachymeter; Pearson's correlation coefficient was calculated.
Main Results:
- No significant correlation was found between central corneal thickness and peripapillary RNFL thickness.
- A significant correlation (P < 0.05) was observed between corneal thickness and other standard GDx parameters.
Conclusions:
- Peripapillary RNFL thickness measurements are not significantly influenced by central corneal thickness.
- Standard GDx parameters, however, demonstrate a significant correlation with corneal thickness, suggesting potential confounding factors in their interpretation.