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TmDOTA-: a sensitive probe for MR thermometry in vivo
C S Zuo1, A Mahmood, A D Sherry
1Department of Radiology, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, Massachusetts 02215, USA. czuo@caregroup.harvard.edu
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|July 11, 2001
Summary
Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-) shows high temperature sensitivity for MR thermometry. This stable agent is insensitive to pH and calcium, making it promising for in vivo temperature measurements.
Area of Science:
- Biomedical Imaging
- Chemical Physics
- Materials Science
Background:
- Magnetic Resonance (MR) thermometry is crucial for monitoring temperature during medical procedures.
- Lanthanide complexes are explored for their potential as contrast agents in MR imaging.
- Thulium complexes offer unique properties for temperature-sensitive applications.
Purpose of the Study:
- To evaluate the potential of thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-) as an agent for in vivo MR thermometry.
- To assess the temperature sensitivity and specificity of TmDOTA- under physiological conditions.
Main Methods:
- Investigated the chemical shifts of TmDOTA- protons.
- Evaluated temperature sensitivity at a clinically relevant magnetic field strength.
- Assessed the influence of pH and calcium (Ca2+) on TmDOTA- chemical shifts.
Main Results:
- TmDOTA- proton chemical shifts demonstrated high sensitivity to temperature changes.
- The agent exhibited insensitivity to variations in pH.
- TmDOTA- was also found to be insensitive to the presence of Ca2+.
Conclusions:
- TmDOTA- exhibits excellent stability, characteristic of lanthanide-DOTA complexes.
- The high thermal sensitivity and specificity of TmDOTA- make it a strong candidate for in vivo MR thermometry.
- Further research is warranted to explore its clinical applicability.