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[Bladder carcinoma producing granulocyte colony-stimulating factor (G-CSF): a case report]
H Kawanishi1, T Aoyama, T Yoshida
1Department of Urology, Shizuoka City Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|August 11, 2001
Summary
Transitional cell bladder cancer can produce granulocyte colony-stimulating factor (G-CSF), leading to severe leukocytosis. Tumor recurrence was associated with G-CSF production and rapid disease progression.
Area of Science:
- Oncology
- Hematology
Background:
- Transitional cell bladder cancer is a common malignancy.
- Paraneoplastic syndromes can occur with various cancers.
Observation:
- An 84-year-old male presented with leg edema and fatigue.
- He had a history of transitional cell bladder cancer treated with transurethral resection.
- Computed tomography revealed an extravesical bladder tumor with significant leukocytosis (46,900/mm3) and elevated granulocyte colony-stimulating factor (G-CSF) (226 pg/ml).
Findings:
- Partial cystectomy was performed for the recurrent tumor.
- Histological diagnosis confirmed transitional cell carcinoma, grade 3.
- Immunohistochemistry confirmed G-CSF production by the tumor.
- Post-surgery, leukocytosis resolved but recurred with intrapelvic tumor recurrence.
Implications:
- This case highlights a rare paraneoplastic syndrome caused by bladder cancer producing G-CSF.
- Elevated G-CSF and leukocytosis can indicate tumor recurrence.
- Prompt recognition and management of G-CSF-producing tumors are crucial for patient outcomes.