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Template images for nonhuman primate neuroimaging: 2. Macaque.
K J Black1, J M Koller, A Z Snyder
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. kevin@npg.wustl.edu
Neuroimage
|August 17, 2001
Summary
Researchers developed 3D neuroimaging templates for pig-tailed macaques (Macaca nemestrina) to enable multi-subject voxel-based analysis. These templates ensure reliable and valid automatic image registration, facilitating cross-species comparisons in brain research.
Area of Science:
- Neuroscience
- Primate Neuroimaging
- Medical Imaging
Background:
- Neuroimaging studies in macaques, like Macaca nemestrina, are growing.
- Individual subject analysis is limited; multi-subject voxel-based analysis requires accurate coregistration.
- High-quality 3D template images are essential for voxel-based coregistration.
Purpose of the Study:
- To create reliable 3D neuroimaging templates for Macaca nemestrina.
- To enable voxel-based analysis across multiple subjects.
- To facilitate cross-species comparisons with baboon templates.
Main Methods:
- Generated templates from T1-weighted MRI and blood-flow PET images of 12 Macaca nemestrina.
- Designed templates for compatibility with baboon templates for cross-species analysis.
- Validated automatic image registration accuracy to the macaque templates.
Main Results:
- Developed T1-weighted MRI and PET-based 3D templates for Macaca nemestrina.
- Achieved an overall mean alignment accuracy of 1.9 mm, even across species.
- Templates are publicly available and compatible with standard image registration software.
Conclusions:
- The created Macaca nemestrina templates are reliable and valid for neuroimaging analysis.
- These templates support multi-subject voxel-based studies and cross-species comparisons.
- The availability of these templates advances primate neuroimaging research.