[Formulation of calcium acetate tablets]

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Calcium acetate is a widely used pharmaceutical compound.
• Optimizing tablet formulation is crucial for drug efficacy and patient compliance.
• Existing production methods for calcium acetate tablets require evaluation.

Purpose of the Study:

• To compare the quality of calcium acetate tablets produced by direct compression and wet granulation.
• To identify the optimal excipient for calcium acetate tablet formulation.
• To assess compliance with pharmaceutical standards (Ph. Jug. IV).

Main Methods:

• Calcium acetate tablets were manufactured using direct compression and wet granulation techniques.
• Key tablet properties including hardness, friability, and disintegration time were measured.
• Maize starch was evaluated as a key excipient in the formulations.

Main Results:

• Tablets produced with maize starch demonstrated the best overall physical properties.
• Both direct compression and wet granulation methods yielded acceptable tablets.
• Maize starch incorporation resulted in enhanced tablet hardness and disintegration.

Conclusions:

• Maize starch is a suitable excipient for calcium acetate tablet production.
• The tested production methods are efficient and yield compliant pharmaceutical preparations.
• Optimized calcium acetate tablets can be rapidly and simply manufactured.