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Related Experiment Videos

Oxygen-free radical decrease in hypertensive patients treated with lercanidipine.

L Incandela1, G Belcaro, M R Cesarone

  • 1Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University, Chieti, Italy.

International Angiology : a Journal of the International Union of Angiology
|September 5, 2001
PubMed
Summary
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Lercanidipine treatment significantly reduced blood pressure and decreased oxidative stress markers in hypertensive patients. This suggests lercanidipine may help slow cardiovascular disease progression, especially in those with high oxidative stress.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Oxidative stress, lipoproteins, and cardiovascular risk factors are linked to vascular disease progression.
  • Measuring free radicals (FRs) offers new insights into these relationships.
  • Hypertension management is crucial for cardiovascular health.

Purpose of the Study:

  • To evaluate changes in blood plasma oxygen free radicals (FRs) in hypertensive patients treated with lercanidipine.
  • To assess the impact of lercanidipine on blood pressure and microcirculation.
  • To determine if lercanidipine affects oxidative stress levels.

Main Methods:

  • Twenty-two hypertensive patients (age 52) without vascular disease were treated with lercanidipine (10-20 mg/day) for 24 weeks.

Related Experiment Videos

  • Blood pressure was monitored regularly throughout the treatment period.
  • Free radical (FRs) levels were measured using the D-Roms test at baseline and at weeks 8, 12, and 24.

    • Main Results:

    • Lercanidipine treatment was well-tolerated with no reported side effects.
    • Significant reductions in systolic and diastolic blood pressure were observed by week 12 and 24 (p<0.05).
    • Plasma free radical (FRs) levels progressively decreased from baseline (541 AU) to 398 AU by week 24 (p<0.02).

    Conclusions:

    • A simple test for measuring FRs can identify individuals with high oxidative stress and monitor treatment effects.
    • Lercanidipine effectively reduces blood pressure and decreases oxidative stress (FRs levels).
    • Lercanidipine may decrease cardiovascular disease progression, offering enhanced protection for patients with high oxidative stress.