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Cortisol, insulin and leptin during space flight and bed rest
T P Stein1, M D Schluter, M J Leskiw
1Department of Surgery, University of Medicine and Dentistry of New Jersey-SOM, Stratford 08084, USA.
Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|September 7, 2001
Summary
Ground-based models for muscle atrophy and bone loss have limitations. Investigating differences, like cortisol, ACTH, leptin, insulin, and food intake, refines these models for space flight research.
Area of Science:
- Physiology
- Space Medicine
- Biochemistry
Background:
- Ground-based models are crucial for studying space flight effects like muscle atrophy and bone loss.
- Existing models show fidelity but have discrepancies compared to actual space flight conditions.
Purpose of the Study:
- To investigate key differences between ground-based models and space flight conditions.
- To provide insights into human physiological responses during space flight.
- To refine existing ground-based models for improved accuracy.
Main Methods:
- Comparative analysis of physiological data from ground-based studies and space flight.
- Examination of hormonal and metabolic markers.
- Focus on the interrelationships between specific biomarkers and physiological outcomes.
Main Results:
- Identified discrepancies in the relationship between cortisol and protein loss.
- Observed differences in the cortisol and ACTH (adrenocorticotropic hormone) relationship.
- Highlighted variations in the interplay of leptin, insulin, and food intake.
Conclusions:
- Understanding these specific differences is vital for accurate human space flight research.
- Refinements based on these findings will enhance the predictive power of ground-based models.
- Further research is needed to fully elucidate these complex physiological interactions.