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A prospectus on tissue adhesives
T B Reece1, T S Maxey, I L Kron
1Department of Surgery, Division of Thoracic and Cardiovascular Surgery, The University of Virginia Health Sciences Center, Box 801359, Charlottesville, VA 22908, USA. treece@lsuhsc.edu
American Journal of Surgery
|September 22, 2001
Summary
Surgical tissue adhesives, including fibrin sealants and newer options like cyanoacrylates and hydrogels, are reviewed. The summary covers their current and future clinical applications for surgeons.
Area of Science:
- Surgical Innovation
- Biomaterials Science
- Clinical Medicine
Background:
- Tissue adhesives are integral to modern surgical procedures.
- Fibrin sealants represent the most widely used category of surgical adhesives.
- Recent advancements have introduced novel adhesive options to the surgical market.
Purpose of the Study:
- To provide a comprehensive review of currently available tissue adhesives.
- To highlight the clinical applications and future potential of various surgical adhesives.
- To inform surgical professionals about the evolving landscape of tissue adhesion technology.
Main Methods:
- Systematic literature review of approved and emerging tissue adhesives.
- Analysis of product data and clinical trial outcomes.
- Synthesis of information on adhesive properties and applications.
Main Results:
- Fibrin sealants remain the predominant tissue adhesive.
- Newer adhesives include cyanoacrylates, albumin-based compounds, collagen-based compounds, glutaraldehyde glues, and hydrogels.
- Each adhesive type presents unique characteristics for specific surgical needs.
Conclusions:
- The range of available tissue adhesives has expanded significantly.
- Understanding the indications for each adhesive is crucial for optimal surgical outcomes.
- Future research will likely focus on refining existing adhesives and developing new ones with enhanced properties.