Related Experiment Videos
Serum lipids in patients with psoriasis.
Dermatologica
|January 1, 1975
Summary
Patients with psoriasis showed lower total cholesterol but similar triglycerides and phospholipids compared to controls. Altered fatty acid levels in psoriasis may result from scale loss or malabsorption, not a primary lipid disorder.
Area of Science:
- Dermatology
- Biochemistry
- Clinical Medicine
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Lipid metabolism alterations are investigated in various diseases.
Purpose of the Study:
- To investigate serum lipid profiles in patients with psoriasis.
- To determine if psoriasis is associated with a primary lipid abnormality.
Main Methods:
- Comparison of serum lipid concentrations (total cholesterol, triglycerides, phospholipids) between 13 psoriasis patients and healthy controls.
- Analysis of serum triglyceride fatty acids.
- Assessment of plasma free fatty acids (FFA) response to heparin.
Main Results:
- Lower total cholesterol (TC) in psoriasis patients compared to controls.
- No significant differences in serum triglyceride (TG) or phospholipid (PL) concentrations.
- Reduced linoleic acid and increased palmitoleic and myristic acids in serum triglycerides.
- Comparable plasma free fatty acid (FFA) response to heparin.
Conclusions:
- No evidence of a basic abnormality in serum lipid metabolism in psoriasis.
- Observed lipid changes are likely due to selective loss through skin scales or impaired absorption.