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Clavulanate-selective electrodes--application to pharmaceutical formulations.

A M Pimenta1, C M Couto, A N Araújo

  • 1CEQUP/Dep. Química-Física, Fac. de Farmácia, Porto, Portugal.

Fresenius' Journal of Analytical Chemistry
|November 2, 2001
PubMed
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A new clavulanate anion-selective electrode was developed for pharmaceutical analysis. This sensor offers a reliable and efficient method for determining clavulanate concentrations in drug formulations.

Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Pharmaceutical Analysis

Background:

  • Clavulanate analysis is crucial for pharmaceutical quality control.
  • Development of selective and sensitive ion-selective electrodes is an ongoing area of research.

Purpose of the Study:

  • To construct and evaluate a novel clavulanate anion-selective electrode.
  • To apply the developed electrode for the direct potentiometric analysis of pharmaceutical formulations.

Main Methods:

  • Fabrication of a PVC membrane electrode using a specific ion-exchanger and additive.
  • Potentiometric measurements to determine electrode response and linearity.
  • Validation against a reference method for accuracy assessment.

Main Results:

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  • The electrode exhibited a linear concentration response from 2.4 x 10(-3) to 1 x 10(-1) mol dm(-3).
  • Achieved a slope of -59.4+/-0.9 mV decade(-1) with good reproducibility (+/-0.6 mV day(-1)).
  • Demonstrated a rapid response time (<20 s) and low relative errors (<3.5%).

Conclusions:

  • The developed clavulanate anion-selective electrode is suitable for pharmaceutical analysis.
  • Direct potentiometry offers a viable and accurate method for clavulanate determination.
  • The electrode's performance indicates its potential for routine quality control.