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Clavulanate-selective electrodes--application to pharmaceutical formulations
A M Pimenta1, C M Couto, A N Araújo
1CEQUP/Dep. Química-Física, Fac. de Farmácia, Porto, Portugal.
Fresenius' Journal of Analytical Chemistry
|November 2, 2001
Summary
A new clavulanate anion-selective electrode was developed for pharmaceutical analysis. This sensor offers a reliable and efficient method for determining clavulanate concentrations in drug formulations.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Pharmaceutical Analysis
Background:
- Clavulanate analysis is crucial for pharmaceutical quality control.
- Development of selective and sensitive ion-selective electrodes is an ongoing area of research.
Purpose of the Study:
- To construct and evaluate a novel clavulanate anion-selective electrode.
- To apply the developed electrode for the direct potentiometric analysis of pharmaceutical formulations.
Main Methods:
- Fabrication of a PVC membrane electrode using a specific ion-exchanger and additive.
- Potentiometric measurements to determine electrode response and linearity.
- Validation against a reference method for accuracy assessment.
Main Results:
- The electrode exhibited a linear concentration response from 2.4 x 10(-3) to 1 x 10(-1) mol dm(-3).
- Achieved a slope of -59.4+/-0.9 mV decade(-1) with good reproducibility (+/-0.6 mV day(-1)).
- Demonstrated a rapid response time (<20 s) and low relative errors (<3.5%).
Conclusions:
- The developed clavulanate anion-selective electrode is suitable for pharmaceutical analysis.
- Direct potentiometry offers a viable and accurate method for clavulanate determination.
- The electrode's performance indicates its potential for routine quality control.
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