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Related Experiment Videos

Mouse-based phenogenomics for modelling human disease.

J Rossant1, C McKerlie

  • 1Dept of Molecular and Medical Genetics, University of Toronto, and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario M5G 1X5, Toronto, Canada. rossant@mshri.on.ca

Trends in Molecular Medicine
|November 2, 2001
PubMed
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Laboratory mice are essential for studying gene function and human diseases. Large-scale mutagenesis and phenotype assessment tools are key to discovering new disease genes and advancing molecular medicine.

Area of Science:

  • Genetics and Genomics
  • Mammalian Models
  • Molecular Medicine

Background:

  • The laboratory mouse is a primary model organism for in vivo genetic studies.
  • It is crucial for understanding mammalian gene function and modeling human diseases.
  • Existing genetic tools in mice are powerful and broadly applicable.

Purpose of the Study:

  • To highlight the importance of large-scale mutagenesis for identifying novel disease-associated genes.
  • To emphasize the need for advanced tools for assessing clinical phenotypes in mice.
  • To underscore the necessity of infrastructure for managing and distributing mouse mutant resources.

Main Methods:

  • Utilizing large-scale random mutagenesis (gene-driven and phenotype-driven).
  • Developing and employing tools for comprehensive clinical phenotype assessment in mice.

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  • Establishing infrastructure for archiving and distributing mutant mouse lines.

    • Main Results:

    • Large-scale mutagenesis approaches are poised to identify new clinically relevant phenotypes.
    • These approaches can uncover previously unknown genes linked to human disease traits.
    • The development of robust phenotyping tools is critical for success.

    Conclusions:

    • Integrated, multidisciplinary programs are essential for maximizing the utility of mouse models.
    • Exploiting the mouse model effectively requires coordinated efforts in mutagenesis, phenotyping, and resource sharing.
    • These advancements will significantly contribute to the field of molecular medicine.