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Ischemia-induced changes in synaptoarchitectonics of brain cortex and their correction with ascovertin and Leuzea
S V Logvinov1, N V Pugachenko, A V Potapov
1Siberian State Medical University. s_logvinov@mail.ru
Bulletin of Experimental Biology and Medicine
|January 10, 2002
Abstract:
Peroral administration of 70 mg/kg ascovertin and 150 mg/kg Leuzea extract to rats with cerebral ischemia for 5 days prevented destructive changes and decrease in the density of synapses in the cerebral cortex. These preparations activated compensatory and reparative mechanisms underlying plasticity of the synaptic pool, which was realized through hypertrophy and destruction of synaptic contacts. Ascovertin possessed more pronounced cerebroprotective activity than Leuzea extract.