Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The intestinal epithelial stem cell.

Emma Marshman1, Catherine Booth, Christopher S Potten

  • 1School of Biological Sciences, University of Manchester, Manchester, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Staff satisfaction with the use of bedside electronic transfusion checks at three hospitals in London.

Vox sanguinis·2026
Same author

Transforming transfusion safety: Insights from implementing bedside electronic checks at a large UK National Health Service trust.

Vox sanguinis·2026
Same author

A framework checklist for implementing bedside electronic transfusion systems.

Transfusion medicine (Oxford, England)·2025
Same author

Implementing bedside electronic transfusion checks at Barts Health NHS Trust: A study protocol for evaluating the effectiveness and value for money.

Transfusion medicine (Oxford, England)·2025
Same author

Modelling SARS-CoV-2 infection in a human alveolus microphysiological system.

Access microbiology·2024
Same author

Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022.

Transfusion medicine (Oxford, England)·2024
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Adult stem cells, particularly in the intestinal epithelium, are crucial for tissue repair. Understanding their hierarchy is essential for developing effective stem cell therapies.

Area of Science:

  • Stem cell biology
  • Epithelial biology
  • Gastrointestinal research

Background:

  • Adult stem cells have significant therapeutic potential, but their hierarchical organization in epithelial tissues remains unclear.
  • The intestinal epithelium serves as a valuable model for studying stem cell hierarchies due to its polarity and rapid cell turnover.
  • Recent research highlights the potential of adult stem cells, yet a comprehensive understanding of their control mechanisms is lacking.

Purpose of the Study:

  • To explore the role of adult epithelial stem cells, focusing on the intestinal epithelial stem cell.
  • To investigate the organization and control of stem cell hierarchies within epithelial tissues.
  • To underscore the importance of understanding these stem cells for future therapeutic applications.

Main Methods:

Related Experiment Videos

  • Review of current literature on adult epithelial stem cells.
  • Analysis of studies focusing on the small intestinal crypt.
  • Examination of stem cell characteristics in normal and regenerating conditions.

Main Results:

  • The intestinal epithelium presents a distinct model for studying stem cell hierarchies.
  • Studies in the small intestinal crypt offer insights into stem cell behavior.
  • Stem cell characteristics vary in normal versus regenerating tissues.

Conclusions:

  • A deep understanding of adult epithelial stem cells is fundamental for advancing stem cell-based therapies.
  • The intestinal epithelial stem cell is a key focus for understanding tissue regeneration.
  • Further research into stem cell hierarchies is necessary for therapeutic development.