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Published on: February 10, 2012
Noninvasive strategies to image cardiovascular apoptosis
1Department of Radiology, Stanford University School of Medicine, California 94305, USA.
Abstract:
Apoptosis consists of a complex set of biochemical events initiated by an array of different stimuli and enzymatic pathways. There is a set of common morphologic and biochemical features of apoptosis that could be exploited as hot or cold targets to image cardiovascular apoptosis. First, the authors review the potential array of targets that can be used to identify apoptosis. Then, the authors examine the history and current status of radiolabeled annexin V, the agent currently used to image apoptosis.
Insights
This study explores imaging cardiovascular apoptosis by reviewing potential targets and the use of radiolabeled annexin V. It highlights methods for detecting programmed cell death in the heart.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Imaging
Background:
- Apoptosis involves complex biochemical events and pathways.
- Common features of apoptosis can serve as imaging targets.
- Cardiovascular apoptosis imaging is an area of active research.
Purpose of the Study:
- To review potential targets for imaging cardiovascular apoptosis.
- To examine the current status of radiolabeled annexin V for apoptosis imaging.
Main Methods:
- Literature review of apoptosis targets.
- Analysis of radiolabeled annexin V's history and application.
Main Results:
- Identified various molecular and morphological features of apoptosis as potential imaging targets.
- Annexin V is a key agent currently used for imaging apoptosis.
Conclusions:
- Targeting common apoptotic features offers opportunities for cardiovascular imaging.
- Radiolabeled annexin V is a significant tool in current apoptosis detection.
