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Updated: Oct 3, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
The Role of Advanced Imaging in Unmasking Epicardial and Microvascular Ischemia
Domenico Simone Castiello1, Claudia Rocca2, Claudia Assenza2
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; Division of Cardiology, Annunziata Hospital, Cosenza, Italy; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.
Abstract:
Myocardial ischemia in chronic coronary syndromes extends far beyond the presence of obstructive epicardial coronary stenoses. Advanced cardiovascular imaging has emerged as a cornerstone for the identification of the diverse anatomic and functional mechanisms underlying myocardial ischemia, including atherosclerotic coronary artery disease, vasospastic angina, myocardial bridging, and coronary microvascular dysfunction. Coronary computed tomography angiography, cardiac magnetic resonance, and PET provide complementary insights. This article reviews the diagnostic performance, characteristic imaging findings, and contemporary clinical applications of these modalities, highlighting their role in refining phenotypic characterization and enabling a more precise and individualized approach to patients with chronic coronary syndromes.
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