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Vancomycin release from poly(D,L-lactide) and poly(lactide-co-glycolide) disks
Y Ozalp1, N Ozdemir, V Hasirci
1Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara University, Turkey.
Journal of Microencapsulation
|January 29, 2002
Summary
A novel biodegradable polymer system was created for controlled vancomycin release to treat brain abscesses. This system demonstrated predictable drug release, paving the way for advanced therapies.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Brain abscesses require effective antibiotic delivery.
- Controlled drug release systems can improve therapeutic outcomes.
- Biodegradable polymers offer biocompatible solutions for drug delivery.
Purpose of the Study:
- To develop and characterize a biodegradable polymeric system for controlled vancomycin release.
- To investigate the degradation behavior of poly(D,L-lactic acid) (PLA) and its copolymers (PLGA).
- To analyze the in situ vancomycin release kinetics from the polymer disks.
Main Methods:
- Preparation of polymer disks using solvent casting.
- Degradation studies using Scanning Electron Microscopy (SEM), Nuclear Magnetic Resonance (NMR), and Gel Permeation Chromatography (GPC).
- In situ drug release analysis in phosphate-buffered saline (PBS) over two months.
Main Results:
- SEM, GPC, and NMR confirmed polymer degradation over time, with higher glycolide content PLGA degrading faster.
- Preferential degradation of the glycolide component was observed.
- Vancomycin release followed Higuchi kinetics, and release rates were influenced by additives like PLA and PEG.
Conclusions:
- A biodegradable PLA/PLGA system effectively controls vancomycin release.
- The degradation profile is dependent on polymer composition (glycolide content).
- This system holds promise for targeted vancomycin delivery in treating brain abscesses.