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Profound reduction in brain embolization using an endoaortic baffle during bypass in swine
David J Cook1, Kenton J Zehr, Thomas A Orszulak
1Department of Anesthesiology, Mayo Foundation and Mayo Clinic, Rochester, Minnesota, USA. cook.david@mayo.edu
The Annals of Thoracic Surgery
|February 9, 2002
Summary
The Cobra baffle aortic cannula significantly reduced cerebral embolization during cardiopulmonary bypass by 89%. This innovative device shows promise in preventing neurologic injury after cardiac surgery.
Area of Science:
- Cardiovascular Surgery
- Neurology
- Biomedical Engineering
Background:
- Cerebral embolization is a significant risk factor for neurologic injury during cardiopulmonary bypass.
- The Cardeon Cobra Catheter, an endoaortic baffle catheter, was investigated for its potential to mitigate this risk.
Purpose of the Study:
- To evaluate the efficacy of the endoaortic baffle catheter in reducing cerebral embolization during cardiopulmonary bypass in a swine model.
- To quantify the reduction in microsphere emboli reaching the brain with baffle deployment.
Main Methods:
- Sixteen swine underwent cardiopulmonary bypass, with eight utilizing the Cobra baffle and eight serving as controls.
- Fluorescent microspheres were administered to induce embolization under normothermic conditions.
- Brains were explanted post-procedure to quantify microsphere deposition in eight distinct regions.
Main Results:
- The Cobra baffle group demonstrated an 89% reduction in total cerebral embolization compared to controls.
- Embolization was significantly reduced in all brain regions analyzed in the baffle group.
- Key physiological parameters remained comparable between the baffle and control groups during the procedure.
Conclusions:
- The Cobra baffle aortic cannula effectively and profoundly reduces cerebral embolization during cardiopulmonary bypass.
- This device holds potential for decreasing the incidence of postcardiac surgical neurologic complications.