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Related Experiment Videos

Development of the enteric nervous system.

Michael D Bates1

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA. michael.bates@chmcc.org

Clinics in Perinatology
|March 29, 2002
PubMed
Summary
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Genes controlling enteric nervous system (ENS) development are crucial. Mutations in these genes cause ENS dysfunction and Hirschsprung

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The enteric nervous system (ENS) controls gastrointestinal motility.
  • ENS development relies on numerous genes, including transcription factors, signaling molecules, and receptors.

Purpose of the Study:

  • To investigate the role of genes in ENS development and function.
  • To understand the genetic basis of ENS disorders like Hirschsprung's disease.

Main Methods:

  • Analysis of gene function in ENS development.
  • Study of mutations affecting ENS development and function in animal models and humans.

Main Results:

  • Gene mutations disrupt ENS development and function.
  • Specific mutations are linked to Hirschsprung's disease.

Related Experiment Videos

Conclusions:

  • Understanding ENS development mechanisms is key.
  • Elucidation aids in diagnosing, treating, and preventing gastrointestinal motility disorders.