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Randomized clinical trials in breast cancer
Nancy Klauber-Demore1, Susan K Boolbol, Anna M Derossis
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Surgical Oncology Clinics of North America
|April 4, 2002
Summary
Advances in breast cancer treatment have shifted from radical approaches to breast conservation therapy and radiation therapy. These methods, supported by decades of research, improve local control and survival rates for select patients.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Historically, breast cancer treatments were radical and disfiguring.
- Significant progress in breast cancer management has occurred over the last four decades.
- Prospective randomized trials have been instrumental in driving these advances.
Purpose of the Study:
- To provide an overview of key prospective randomized trials in breast cancer treatment.
- To highlight the evolution of breast cancer therapeutic strategies.
- To discuss the impact of recent research on patient management.
Main Methods:
- Review of prospective randomized trials in breast cancer.
- Analysis of treatment outcomes including local control and survival.
- Synthesis of evidence supporting breast conservation therapy and radiation therapy.
Main Results:
- Breast conservation therapy is established as a primary treatment for select breast cancer patients.
- Radiation therapy has been proven to enhance local control and survival rates.
- Numerous trials have demonstrated significant improvements in breast cancer management.
Conclusions:
- Modern breast cancer treatment emphasizes less disfiguring and more effective approaches.
- Prospective randomized trials continue to shape optimal breast cancer care.
- Breast conservation and radiation therapy represent major advancements in improving patient outcomes.