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Related Experiment Videos

Oral heparins.

Linda M Hiebert1

  • 1Department of Veterinary Biomedical Sciences, University of Saskatchewan, Western College of Veternary Medicine, Saskatoon, Canada. linda.hiebert@usask.ca

Clinical Laboratory
|April 6, 2002
PubMed
Summary
This summary is machine-generated.

Oral heparin shows promise for long-term thrombosis prevention. Despite low plasma levels, endothelial cells absorb oral heparin, reducing thrombosis incidence in rats, suggesting potential oral efficacy.

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Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Drug Delivery

Background:

  • Heparin, an antithrombotic agent, is typically administered parenterally.
  • Oral heparin offers advantages for long-term thrombosis prevention.
  • Endothelial cell uptake is a key factor in heparin's action.

Purpose of the Study:

  • To investigate the efficacy and absorption of orally administered heparin.
  • To evaluate endothelial cell uptake of oral heparin.
  • To assess the antithrombotic potential of oral heparin in a rat model.

Main Methods:

  • Administered unfractionated and low molecular weight heparins orally to rats.
  • Measured endothelial heparin concentrations and plasma levels.
  • Assessed thrombosis incidence in a rat jugular vein thrombosis model.

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Main Results:

  • Oral heparin was taken up by endothelial cells, with peak concentrations within 15 minutes.
  • Plasma heparin levels remained below 1% of the administered dose.
  • A dose-dependent reduction in thrombosis incidence was observed for all tested heparins.
  • Low molecular weight heparins demonstrated efficacy at significantly lower doses than unfractionated heparin.

Conclusions:

  • Oral heparin administration leads to endothelial uptake and exhibits antithrombotic effects.
  • Plasma heparin concentration may not accurately reflect total body endothelial-associated heparin.
  • These findings suggest that heparin may be effective via the oral route for thrombosis prevention.