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Related Experiment Videos

Opioid receptor polymorphisms and opioid abuse.

Nancy M Lee1, Andrew P Smith

  • 1California Pacific Medical Center Research Institute, 2330 Clay Street, Stern Bldg., San Francisco, CA 94115, USA. nml@cooper.cpmc.org

Pharmacogenomics
|April 26, 2002
PubMed
Summary

Researchers are investigating single nucleotide polymorphisms (SNPs) in the human genome to understand gene function and disease susceptibility. Specific variations in the mu opioid receptor (MOR) are linked to altered function and increased risk for drug abuse.

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Area of Science:

  • Genetics
  • Pharmacology
  • Neuroscience

Background:

  • The human genome sequencing provides a foundation for understanding gene function and disease.
  • Identifying genetic variations like single nucleotide polymorphisms (SNPs) is crucial for disease research.
  • The mu opioid receptor (MOR) plays a key role in pain perception and mediates the effects of opioids.

Purpose of the Study:

  • To investigate the functional consequences of single nucleotide polymorphisms (SNPs) in the mu opioid receptor (MOR).
  • To determine the association between MOR genetic variations and susceptibility to drug abuse.

Main Methods:

  • Characterization of several dozen known mu opioid receptor (MOR) polymorphisms.
  • Analysis of the correlation between specific MOR SNPs and altered receptor function.

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  • Examination of the frequency of certain MOR SNPs in relation to drug abuse risk.

    • Main Results:

    • Several mu opioid receptor (MOR) polymorphisms exhibit altered receptor function.
    • Specific MOR genetic variations are associated with an increased risk for drug abuse.

    Conclusions:

    • Genetic variations in the mu opioid receptor (MOR) influence its function.
    • MOR polymorphisms represent potential biomarkers for predicting susceptibility to drug abuse.