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Updated: Jul 26, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Butyrylcholinesterase and cognitive function
S Darvesh1, C MacKnight, K Rockwood
1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. sdarvesh@is.dal.ca
Abstract:
Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor. We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction.
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