Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Butyrylcholinesterase and cognitive function.

S Darvesh1, C MacKnight, K Rockwood

  • 1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. sdarvesh@is.dal.ca

International Psychogeriatrics
|May 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interaction of exogenous acetylcholinesterase and butyrylcholinesterase with amyloid-β plaques in human brain tissue.

Chemico-biological interactions·2024
Same author

Sex Moderates the Association between Frailty and Mild Behavioral Impairment.

The journal of prevention of Alzheimer's disease·2022
Same author

Interaction of Exogenous Butyrylcholinesterase with β-Amyloid Plaques in 5XFAD/Butyrylcholinesterase-Knockout Mouse Brain.

Current Alzheimer research·2021
Same author

Imaging Butyrylcholinesterase in Multiple Sclerosis.

Molecular imaging and biology·2020
Same author

Intact olfactory memory in the 5xFAD mouse model of Alzheimer's disease from 3 to 15 months of age.

Behavioural brain research·2020
Same author

Moving Towards Common Data Elements and Core Outcome Measures in Frailty Research.

The Journal of frailty & aging·2020

Selective butyrylcholinesterase (BuChE) inhibitors may impact cognitive function. A patient

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Butyrylcholinesterase (BuChE) is present in brain regions crucial for cognition.
  • The impact of selective BuChE inhibitors on human cognitive function remains largely uninvestigated.

Observation:

  • A single patient experienced cognitive decline when ethopropazine dosage was reduced.
  • Cognitive function improved upon reintroduction of ethopropazine, a selective BuChE inhibitor.

Findings:

  • This case suggests a potential role for BuChE activity in maintaining cognitive function.
  • Ethopropazine's selective inhibition of BuChE was associated with cognitive changes.

Implications:

  • Further research into selective BuChE inhibitors for cognitive dysfunction is warranted.

Related Experiment Videos

  • BuChE-expressing neurons may be a therapeutic target for cognitive disorders.