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Related Experiment Videos

Lactose intolerance.

Daniel L Swagerty1, Anne D Walling, Robert M Klein

  • 1Department of Family Medicine, University of Kansas School of Medicine, Kansas City 66160-7370, USA. dswagert@kumc.edu

American Family Physician
|May 23, 2002
PubMed
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Lactose intolerance, caused by insufficient lactase enzyme, leads to digestive issues. Diagnosis involves history and tests, with management focusing on dietary changes and calcium intake.

Area of Science:

  • Gastroenterology
  • Human Genetics

Background:

  • Lactose intolerance stems from inadequate lactase enzyme activity, hindering lactose digestion.
  • Prevalence varies significantly across ethnic groups, with higher rates in Asian and American Indian populations.
  • Self-diagnosis is common, but not all individuals reporting symptoms have true lactase deficiency.

Purpose of the Study:

  • To outline the pathophysiology, diagnosis, and management of lactose intolerance.
  • To highlight the variability in lactose malabsorption and tolerance.
  • To emphasize the importance of adequate calcium intake in affected individuals.

Main Methods:

  • Clinical history and dietary manipulation are primary diagnostic tools.
  • Breath hydrogen and lactose tolerance tests can confirm diagnosis if needed.

Related Experiment Videos

  • Assessment of individual tolerance levels to lactose-containing foods.

    • Main Results:

    • Lactose intolerance symptoms include abdominal pain, bloating, gas, and diarrhea after consuming lactose.
    • Lactase deficiency prevalence ranges from 15% in Northern Europeans to 100% in Asians and American Indians.
    • Many individuals with lactase deficiency can tolerate moderate amounts of lactose, such as up to 12 oz of milk daily.

    Conclusions:

    • Lactose intolerance diagnosis relies on clinical evaluation and can be confirmed by objective tests.
    • Management involves dietary modifications, avoiding lactose-rich foods, and considering lactase enzyme supplements.
    • Ensuring adequate calcium intake is crucial for individuals with lactose intolerance to prevent deficiencies.