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Synthesis of symmetrical carotenoids by a two-fold Stille reaction
Belén Vaz1, Rosana Alvarez, Angel R de Lera
1Departamento de Química Orgánica, Facultad de Ciencias, Universidade de Vigo. 36200 Vigo, Spain.
The Journal of Organic Chemistry
|July 6, 2002
Abstract:
beta-Carotene 1 and (3R,3'R)-zeaxanthin 2 have been stereoselectively prepared in a highly convergent fashion by a 2-fold Stille cross-coupling reaction. The C(12)-pentaenylbis-stannane 8 is the central "lynchpin" that connects two units of the terminal C(14)-iodides 9 and 17 to afford 1 and 2, respectively.