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A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases
David A Brown1, William Errington, Noel J Fitzpatrick
1Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Chemical Communications (Cambridge, England)
|July 12, 2002
Abstract:
Reaction of Zn(OAc)(2).2H2O with tmen leads to the formation of [Zn(tmen)(OAc)2] (I) which reacts with benzohydroxamic acid to form Zn(BA)2.H2O (II) and the novel dizinc hydroxamate bridged complex [Zn2(mu-OAc)2(OAc)(mu-BA)(tmen)] (III), which may also be prepared by self-assembly and whose structure closely mimics that of the native hydroxamate inhibited Aeromonas proteolytica aminopeptidase.