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Development of insulin resistance in experimental animals during long-term glucocorticoid treatment
V G Selyatitskaya1, O I Kuz'minova, S V Odintsov
1Laboratory of Endocrinology, Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. ccem@cyber.ma.nsc.ru
Bulletin of Experimental Biology and Medicine
|July 19, 2002
Abstract:
Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.