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Primary cutaneous lymphoblastic lymphoma presenting in an 8-week old infant
Jacqueline K Trupiano1, Karen Bringelsen, Eric D Hsi
1Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Background:
We report a case of primary cutaneous lymphoblastic lymphoma (LBL) presenting in an 8-week-old infant.
Methods:
Histopathology and flow cytometric analysis confirmed the diagnosis of a lymphoblastic lymphoma. The cells expressed CD19, CD20, CD34 and surface immunoglobulin (sIg).
Results:
The cells were negative for TdT and CD99. This unusual immunophenotype has been described as "transitional pre-B-cell", in that the cells express both immature markers (CD34) and mature markers (sIg).
Conclusions:
To our knowledge, only five other cases of sIg positive precursor B-cell LBL have been reported in the literature. This may represent the youngest reported case of primary cutaneous LBL, occurring at 8weeks of age.